Aqueous Ziziphus mauritiana leaf extract pretreatment shields albino rats' livers against alcohol-induced damage

T.Swathi,T.Vijayalakshmi ,Shilpadas ,Maheen Zuberiya

» doi: http://https://ijpsl.co.in//.2020.v10.i02.pp25-29

Abstract

In chronic alcohol-induced liver damage, the impact of an aqueous extract of Ziziphus mauritiana leaf on hepatic lipid peroxidation, decreased glutathione, and overall antioxidant status was investigated. Method: Rats were given an oral 40% alcohol solution (v/v, 1 ml/100 g) for six weeks in order to cause liver damage. Before consuming alcohol, rats in other groups received pretreatment in the form of 200 and 400 mg/kg bw aqueous extracts of Ziziphus mauritiana leaf or 100 mg/kg bw silymarin (reference medication) 30 minutes beforehand. Rats' body weight was recorded once a week. The following biomarkers were assessed: reduced glutathione, lipid peroxidation, total bilirubin, aspartate aminotransferase (AST), and liver total antioxidant status.Results: Compared to control rats, animals given alcohol alone had considerably (p<0.05) higher levels of ALT, AST, bilirubin, and hepatic lipid peroxidation, and significantly (p<0.05) lower levels of glutathione, total antioxidant status, and body weight. Rats who received an aqueous extract of Ziziphus mauritiana thirty minutes before being administered alcohol showed a substantial (p<0.05) decrease in their levels of ALT, AST, bilirubin, and lipid peroxidation when compared to the group that simply received alcohol. When compared to the group that only received alcohol, the administration of Ziziphus mauritiana extract before alcohol consumption substantially (p<0.05) raised levels of reduced glutathione and overall antioxidant status. In conclusion, the study's findings suggest that by raising total antioxidant status levels and preventing hepatic lipid peroxidation, an aqueous extract of Ziziphus mauritiana leaf may protect against long-term alcohol-induced liver damage.